Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: 86-139-10575315
Tel: +86 15632961819
Tel: +86 18233902561
Tel: +86 15717685612
Tel: +86 16630923639
Tel: +86 18732968538
Tel: +86 18833033983
Tel: +86 19831957301
Mobile: +86 19831957301
Tel: 86-139-10575315
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: Congtai District, La Defense North
MaxCard:
Ms.AnnaCAS NO.84603-62-3
Pharmaceutical grade(1-50)KilogramPharmaceutical grade(51-99)Kilogram
Our Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
. Return to lung and stomach. The patient was mainly treated with heat-clearing and detoxification, evacuation of wind-heat, cooling blood and stopping dysentery. The patient was diagnosed with extrinsic wind-heat, beginning with blast, Head Pain, thirst, Cough, dry throat, sore throat, sore, erysipelas, heat toxin and blood dysentery.
| Plant Source: | honeysuckle |
| plant extract | honeysuckle is a common traditional Chinese medicine in China, which is the dried flower bud of Lonicera japonica Thunb. Honeysuckle extract obtained after extraction and drying has been widely used in yinhuang Oral Liquid, yinhuang capsule, yinhuang granules and other proprietary Chinese medicines. Chlorogenic acid, the main active ingredient in honeysuckle extract, has the pharmacological effects of anti-virus, improving immunity and lowering blood lipid. Honeysuckle extract in the pharmaceutical, spices, cosmetics, health food, health drinks and other fields gradually should be, the prospect is very broad. |
| extracted from | honeysuckle is the dried flower bud or just-open flower of Lonicera japonica Thunb. Also known as Lonicera japonica flower, quails flower, silver flower, double flowers, two flowers, golden vine flower, double bud flower, Golden Flower, two flower Flower, leaf Vine, Tea Flower. In the altitude of 1500m in the Hill, Valley, forest, side hedges, wild or cultivated, often round ornamental shade plants. It is distributed in most parts of China. Mainly produced in Henan and Shandong. Henan production is called "South Yinhua", Shandong production is called "East Yinhua" or "Ji Yinhua". Climbing shrubs, 3-6 m in length. Young branches were densely pilose and glandular trichomes. Leaves opposite, with short sessile; Leaf blade broadly-linear or elliptic, 3-8cm long, 2-4cm wide, apex acuminate, base rounded, entire. Flowers paired in leaf axillae; Bracts 1 pair, leaf-like, bracteoles free; Calyx tube hairless, calyx teeth 5, apiculate and ciliated; Corona tube-like, 3-4cm long, first white, then light yellow, aromatic, lipped, upper lip 4-lobed upright, lower lip inverted; Stamens 5. Berries spherical, black. Flowering period May -8 months, fruiting period 8-9 months. |
| Chemical composition | 1. The main effective component of the organic acid honeysuckle extract is chlorogenic acid compound. There are mainly chlorogenic acid (Chlorogcnic acid) and isochlorogenic acid (isochlorogenic acid). Chlorogenic acid (CGA), also known as coffee tannic acid, is a condensed phenolic acid formed by caffeic acid and quinic acid, belonging to phenylpropanoid compounds. Isochlorogenic acid as a mixture, its isomers were 4, 5-dicaffeic acid quinic acid, 3, 4-dicaffeic acid quinic acid, 3, 5-dicaffeic acid quinic acid, 1, 3-dicaffeic acid acylquinic acid, 3-feruloylquinic acid, 4-feruloylquinic acid, 5-feruloylquinic acid. The first flavonoid extracted from Flos lonicerae is luteolin, followed by Lonicera glycoside. Four flavonoids, luteolin-3-o-α-d-glucoside, luteolin-7-O-β-D galactoside, quercetin-7-o-β-d-glucoside and hyperin, were isolated from n-butanol extract of Lonicera japonica Thunb. 5-hydroxy-3 ',4', 7-trimethoxyflavone and Corymbosin were separately obtained from the chloroform extract of honeysuckle. 3. The volatile oil has the flower alcohol, linalool. The two accounted for 49.4% of the total volatile oil. It also contains eugenol, geraniol, α-terpineol and so on, and 47 compounds have been identified. Other still containing inositol, saponin, tannic acid, etc. Chlorogenic acid: molecular formula C16H18O9, molecular weight 354.30. The hemihydrate was a needle-like crystal (water) which became an anhydrous compound at 110 ° C., MP. 208 ° C.,[α]D26-35.2 °(C = 2.8). 25 ° C water solubility of 4%, hot water solubility greater, soluble in ethanol and acetone, very slightly soluble in ethyl acetate. Honeysuckle leaves contain Loniceraflavone (Loniceraflavone): Molecular formula C15H10O5, Lonicein (Lonicein), Loganin (Loganin) and tannin. |
| pharmacological action | 1. Anti-inflammatory, antipyretic and anti-allergic effects honeysuckle extract can inhibit carrageenan-induced foot swelling in rats and reduce the degree of egg white-induced foot swelling. It also has obvious anti-exudative and anti-proliferative effects on Croton oily granulation capsule in rats. Honeysuckle has obvious antipyretic effect on experimental animal Fever model. Yinqiao powder has a significant inhibitory effect on a variety of experimental inflammation, especially allergic inflammation, and can obviously inhibit Fever of rats induced by 2, 4-Dinitrophenol. 2. Anti-Fertility Effect of honeysuckle ethanol extract decoction after non-oral administration has obvious anti-fertility effect, intraperitoneal injection of mice early, middle and late pregnancy are effective, intravenous drip or intrauterine administration is also effective for early pregnancy in rabbits. Honeysuckle can make early pregnancy rat plasma progesterone decreased significantly, the anti-early pregnancy effect of honeysuckle can be exogenous progesterone, human chorionic gonadotropin (HCG) completely canceled, flos lonicerae can also significantly inhibit the formation of decidual tumor in pseudopregnant mice, and this effect can also be antagonized by progesterone. 3. Antioxidant effect the aqueous extract of Lonicera japonica has a direct elimination effect on hydrogen peroxide (H2O2) in vitro and a linear dose-effect relationship, but whether it has a role in vivo remains to be further studied. In addition, honeysuckle can improve the release of H2O2 from neutrophils in scalded mice to a certain extent, and can reduce the ability of neutrophils to synthesize and release lysosomal enzymes in scalded mice, indicating that it has the effect of antioxidant response. The results showed that the crude extract of chlorogenic acid and the crude flavonoids had significant inhibitory effect on the peroxidation of oil. Honeysuckle glycosides and chlorogenic acid are two kinds of phenolic acid compounds with high content in Lonicera japonica leaves. Phenolic acid is a kind of typical compounds with free radical scavenging effect, and honeysuckle glycosides is slightly stronger than chlorogenic acid. The antioxidant activity of Flos lonicerae was studied by DPPH method, and the antioxidant activity was expressed by inhibition rate. When the concentration of Flos lonicerae is 5 mg/mL, the inhibition rate is 95.4%, and when the extract is diluted 5 times, the concentration is 1 mg/ml, the inhibition rate is 94.3%, which indicates that Flos lonicerae has strong antioxidant ability. 4. The chlorogenic acid contained in the extract of liver and gallbladder honeysuckle has beneficial biliary effect and can enhance the secretion of bile in rats. Hypodermic injection of 200mg/kg of total saponins from Lonicera fulvotomentosa can significantly antagonize the increase of GPT in liver and the content of triglyceride in liver induced by CCl4, paracetamol and galactosamine, and obviously reduce the severity of liver pathological injury, the sum of the number of liver punctate necrosis and the occurrence rate of necrosis were significantly reduced. Hypolipidemic, enhance immune function rats intragastric 2.5g/kg honeysuckle extract, can reduce intestinal cholesterol absorption, lower plasma cholesterol levels. In vitro tests also found that honeysuckle can be combined with cholesterol. Total saponins of Lonicera fulvotomentosa can significantly reduce the content of liver triglyceride in normal mice, and the content of liver triglyceride in mice poisoned by CCl4, paracetamol and galactosamine. Flos lonicerae aqueous extract can promote the phagocytic function of peripheral blood leukocytes. Intraperitoneal injection of Flos lonicerae injection could also promote the phagocytosis of inflammatory cells. 250mg/kg aqueous extract of Flos lonicerae can reduce the percentage of ANAE positive T cells, suggesting that it may have inhibitory effect on cellular immunity. In addition, chlorogenic acid has the function of increasing white blood cells as the main active ingredient of ramie. 6. Hemostatic effect chlorogenic acid and caffeic acid contained in honeysuckle extract have significant hemostatic effect, which can shorten the coagulation time and bleeding time. Chlorogenic acid and caffeic acid are also effective hemostatic components of ramie root. Chlorogenic acid is not resistant to high temperature, long time heating will destroy and reduce the efficacy. Traditional hemostatic silver flower charcoal, may be related to this. Central excitatory action oral chlorogenic acid can cause rats, mice and other animals in the central nervous system excited, the intensity of caffeine 1/6, the combination of the two no additive and enhance the role. 8. Antibacterial, antiviral effect honeysuckle extract antibacterial range is wide, the Staphylococcus aureus, hemolytic Streptococcus, Pneumonia Diplococcus, Bordetella pertussis and other Gram-positive bacteria have inhibitory effect, and Shigella dysenteriae, Salmonella Typhi, paratyphoid bacilli, Vibrio cholerae, Pseudomonas aeruginosa, Escherichia coli, human tuberculosis, Meningococcus and other Gram-negative bacteria also have a strong inhibitory effect on Leptospira is also effective. The water decoction of this product has in vitro inhibitory effect on a variety of dermatophytes, such as Trichophyton panularis, xanthophyton Xu, Trichophyton Rustum, epidermal ringworm, and so on. Recent studies have shown that honeysuckle has antibacterial effect on the common pathogenic bacteria of oral diseases, such as Streptococcus mutans, Actinobacillus, gingivalis, and melanin producing Bacillus. Honeysuckle or its compound, on the respiratory tract Virus such as influenza Asia A, orphan Virus has inhibitory effect, and can inhibit and delay the cytopathic effect. In addition, the herpes Virus also has a certain inhibitory effect. It is generally believed that the main active ingredient is a chlorogenic acid compound. Other effects in vitro the water and alcohol extracts of Flos lonicerae have obvious cytotoxic effects on sarcoma S180 and Ehrlich ascites carcinoma in mice. Oral administration of honeysuckle extract has mild preventive effect on pylorus ligated gastric ulcer in rats. Oral administration of large doses of chlorogenic acid can enhance gastrointestinal peristalsis, promote gastric juice and bile secretion. Chlorogenic acid and its decomposition products have Excitatory effect on isolated rat uterus. Chlorogenic acid contained in Flos lonicerae can stimulate the central nervous system of rats and mice. In addition, chlorogenic acid can slightly enhance the pressor effect of epinephrine and norepinephrine on cats and rats, but has no effect on the instantaneous membrane reaction of cats. |
| extraction method | 1.1kg of honeysuckle was extracted by sulfur method, and then decocted with water for 2H each time. The combined decoction was filtered, and the filtrate was adjusted to pH 10~12 by adding lime milk, adjust the pH value with sulfuric acid to 6~7, stir, filter, filtrate is concentrated to thick paste, spray drying, then get honeysuckle extract. 2.1kg of honeysuckle was taken by modified sulfur method, and (15, 10) times the amount of water, extracted 2 times at 80~90 ℃, 2h each time, filtered, combined with filtrate, after the filtrate is concentrated to 2 /5 of the original volume, add 20% lime milk to adjust the pH value to 10~12, stand for 12h, filter out the precipitate, add 2 times the amount of 95% ethanol for suspension, add 50% sulfuric acid to adjust Ph 3~4, The filtrate was adjusted to pH 6-7 with 40% NaOH, filtered, concentrated to a thick paste, and spray-dried to obtain honeysuckle extract. 3. Take honeysuckle 1kg by ultrafiltration, add (15, 10) times the amount of water, decocting 2 times, 2h each time, filtering, combined filtrate, filtrate concentrated to the original volume of 2/5, the ultrafiltrate was collected and concentrated to a raw dose. The solution was allowed to stand, filtered, concentrated under reduced pressure, and vacuum dried to obtain honeysuckle extract. 4. Reflux extraction with ethanol, weigh 1kg of honeysuckle, put it in a round bottom flask, add (10, 8) times the amount of 70% ethanol, heat reflux extraction 2 times, 2h each time, filter, combine the filtrate, concentrate under reduced pressure, The honeysuckle extract was obtained by vacuum drying. 5. Macroporous adsorption resin treatment to take honeysuckle 1kg, add (15, 10) times the amount of water, 90 ℃ extraction 2 times, 2h each time, filtration, combined filtrate, the filtrate was added to the pretreated macroporous adsorption resin, and eluted with water. The eluate was collected, concentrated under reduced pressure, and vacuum dried to obtain honeysuckle extract. Fig.3 extraction and separation of chlorogenic acid fig.4 extraction and separation of polysaccharide |
| Application | honeysuckle extract is gradually applied in the fields of pharmacy, spices, cosmetics, health food, health drinks, etc, the prospect is very broad. In the pharmaceutical aspect has been developed by the traditional Chinese medicine formula of fried Liu into tablets, injections, pills, granules, ointments and other types: in the perfume industry has developed honeysuckle perfume, honeysuckle shampoo, etc.; In the beverage aspect has developed honeysuckle tea, honeysuckle shower, silver wheat beer spray and so on these products are favored by domestic and foreign consumers. |
| medicinal property | |
| safety toxicology analysis | the toxicity of Flos lonicerae Japonicae is very small. The water extract has no obvious toxicity to rabbits and dogs, blood pressure, urine volume and so on had no effect, mice subcutaneous injection of honeysuckle extract LD50 53 g/kg. Chlorogenic acid has a sensitizing effect, can cause allergic reactions, but oral administration without this reaction, because chlorogenic acid can be converted into small intestinal secretions into non-allergenic substances. The LD50 of chlorogenic acid to young rats was more than 1 g/kg, and the intraperitoneal injection was more than 0.25 g/kg. Hypodermic injection of total saponins of Lonicera fulvotomentosa in mice LD50 was 1.08g/kg, poisoning symptoms of spontaneous activity decreased, respiratory depression died. |
| Use | for organic synthesis and used as pigment, pharmaceutical intermediate |
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.