Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: 86-139-10575315
Tel: +86 15632961819
Tel: +86 18233902561
Tel: +86 15717685612
Tel: +86 16630923639
Tel: +86 18732968538
Tel: +86 18833033983
Tel: +86 19831957301
Mobile: +86 19831957301
Tel: 86-139-10575315
Fax: 4001020630
URL: https://www.nengqianchemical.com/
Province/state: Hebei
City: Handan
Street: Congtai District, La Defense North
MaxCard:
Ms.AnnaCAS NO.863-61-6
Pharmaceutical grade(1-50)KilogramPharmaceutical grade(51-99)Kilogram
Our Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 238.0±29.0 °C at 760 mmHg |
| Molecular Formula | C10H14O |
| Molecular Weight | 150.218 |
| Flash Point | 95.6±0.0 °C |
| Exact Mass | 150.104462 |
| PSA | 17.07000 |
| LogP | 2.68 |
| Vapour Pressure | 0.0±0.5 mmHg at 25°C |
| Index of Refraction | 1.543 |
| Storage condition | 2-8°C |
| Introduction | Vitamin K is a class of compounds with quinone structure, including 5 kinds of different structure compounds, namely vitamin K1, k2, K3, K4, K5. Studies have shown that vitamin K2 has the effect of osteogenesis, promoting calcium metabolism, and inhibiting bone resorption caused by osteoclasts, thereby increasing bone density and preventing osteoporosis. Vitamin K2 is a series of compounds, light yellow crystals, mainly synthesized by intestinal bacteria, according to the length of the isoprene side chain on C3, a total of 14 kinds, mainly used for the treatment of osteoporosis is vitamin K2(20), I .e., tetraenmenadione. Tetraenmenadione is an oily substance, and has the characteristics of light and easy decomposition, so it is suitable for making soft capsule dosage form. |
| trait | a yellow crystal obtained from acetone-ethanol or methanol-chloroform with a molecular weight of 580.90, melting point of 51~52 ℃, insoluble in water, slightly soluble in oil, soluble in ethanol, ether, acetone, benzene, chloroform and other organic solvents, but its solubility is slightly worse than Vitamin K1. It is decomposed by the action of strong acid, oxidant, alkali and light. It is found in green leaves and vegetables, as well as in fish, meat, cheese, and liver oil. It can be extracted from millet leaves and rotted fish meat, and can also be synthesized from 2-methylnaphthoquinone-1, 4 as raw material. It can promote blood coagulation, and is an effective fat-soluble vitamin for controlling blood coagulation. For the treatment of gallbladder disease and neonatal hemorrhage. |
| physiological functions | tetraenmenadione is a naturally occurring vitamin containing the basic structure of menadione and having an anti-bleeding effect, demm discovered that there are two kinds of vitamin K in nature, K1 and K2, both of which are naphthoquinone compounds. This product is yellow crystal or oily liquid, insoluble in water, soluble in organic solvents and vegetable oil, heat resistant, but easy to be damaged by light. tetraenmenadione can promote the synthesis of prothrombin in the liver, regulate the synthesis of coagulation factors VII, IX, X, and accelerate blood coagulation. In addition, it plays an important role in glucose phosphorylation in cells. In some bacteria (e. G., mycobacteria), it can be used as a component of the respiratory chain. After the lack, the duration of bleeding is prolonged, so there will be bleeding in the presence of trauma. Bacteria in the intestines of humans and animals can be synthesized, so it is generally not easy to get deficiency. |
| deficiency | human intestinal bacteria can produce tetraenmenadione (vitamin K2), so there is no risk of deficiency. However, such as long-term use of sulfonamides or antibiotics to inhibit bacteria, or any cause of lipid malabsorption: such as bile duct obstruction, fat stool, tropical Diarrhea, pancreatic dysfunction, etc, both will lead to vitamin K deficiency. Usually harmless minor injuries can also cause bleeding and death in animals lacking K. Therefore, patients with intestinal obstruction and bile duct obstruction must be injected with vitamin K before surgery. Newborn infants can also occur in the absence of sterile intestinal cavity K neonatal hemorrhagic disease, can continue to the intestinal cavity until the bacteria. Prenatal K injection to pregnant women can be prevented. Such as direct injection of newborns should not be too much, so as not to cause hyperbilirubinemia and jaundice. There is no risk of vitamin K deficiency in adults as long as intestinal fat is well absorbed. It is well known that in patients with a deficiency of vitamin K, prothrombin in the blood is reduced and the bleeding time is prolonged. Therefore, it is considered that the main function of K is to promote the synthesis of prothrombin in the liver. After years of research found that vitamin K on Coagulation Factors VII, IX, X in the liver in the production also has a role in promoting. In the absence of K, these blood coagulation factors will decrease. Because of this, when suffering from liver cancer or cirrhosis, liver tissue is severely damaged, liver function is abnormal, even if Vitamin K is administered. |
| mechanism of action | the biochemical mechanism of action of vitamin K has been debated. Recently, it was not thought to promote the biosynthesis of the protein prothrombin, but only to convert the N-terminal 10 glutamic acid residues of the proenzyme precursor molecule into the thrombin that can bind to Ca2. It is clear that the gamma carboxylated glutamate residue is where prothrombin binds to CA2. This gamma carboxylation requires the participation of vitamin K. Gamma carboxylation may be widespread. Vitamin K is important for the synthesis of all four coagulation factors. |
| biological activity | Vitamin K2 (Menaquinone) is a very important fat-soluble Vitamin in the protection of the heart and brain, plays an important role in the process of building strong bones. |
| Menatetrenone Usage And Synthesis |
| Description | Menatetrenone (also known as MK-4) is a manaquinone compound and a vitamin K compound which can be used as a hemostatic agent as well as adjunctive therapy for the pain of osteoporosis. It mainly takes effects through modulating the signaling of certain tyrosine kinases, thereby affecting several transcription factors including c-myc and c-fos. It is capable of inhibiting tumor cells growth through inducing apoptosis and cell cycle arrest. It can be produced via the conversion of vitamin K1 inside the body including the testes, pancreas and arterial walls. |
| Chemical Properties | A yellow crystal is extracted from acetone-ethanol or methanol-chloroform. It has a molecular weight of 580.90 and a melting point of 51-52°C. It is insoluble in water but slightly soluble in oil. It dissolves well in ethanol, ether, acetone, benzene, chloroform, and other organic solvents. However, its solubility is slightly lower than that of vitamin K1. It decomposes when exposed to strong acid, oxidants, alkalis, and light. |
| Occurrence | Menatetrenone (vitamin K2) is widely found in green leaves and vegetables, and also in fish, meat, cheese and liver oil. |
| Uses | Menaquinones are isoprenoid quinones of the naphthalene series and belongs to the K2 Vitamin homologs. Menaquinones were originally discovered as the anti-hemorrhagic factor and now encompasses a variety of physiological processes. Menaquinone 4 has four isoprene residue in its side chain and is also commonly refered to as menatetrenone. Menaquinone-4 is the most common type of vitamin K2 and is known as a hemostatic agent and is used as adjunctive therapy for the pain of osteoporosis. |
| Definition | ChEBI: Menaquinone-4 is a menaquinone whose side-chain contains 4 isoprene units in an all-trans-configuration. It has a role as a bone density conservation agent, a human metabolite, an antioxidant, an anti-inflammatory agent and a neuroprotective agent. |
| Preparation | It can be extracted from millet leaves and rotten fish, and can also be synthesized with 2-menaquinone-1,4. |
| General Description | Menaquinone (K2), a vitamin K2 homologue with four isoprene units. It has been reported to enhance bone formation and plays a vital role in the production of blood coagulation factors. |
| Biochem/physiol Actions | Menatetrenone (MK-4) is one of nine forms of vitamin K2 which is ubiquitously present in extrahepatic tissues. MK-4 has a number of metabolic and anti-neoplastic activities. |
| References | # # |
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.