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Hebei Nengqian Chemical Import and Export Co., LTD

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Hebei Nengqian Chemical Import and Export Co., LTD

Country: China (Mainland)

Business Type:Trading Company

Ms.Winnie

Tel: +86 18233902561

Mobile: +86 18233902561

Tel: +86 18233902561

Fax: 4001020630

URL: https://www.nengqianchemical.com/

Province/state: Hebei

City: Handan

Street: No.1722, Block C, Yangguang Xinzhuo Plaza, 256 Renmin West Road, Fuxing District, Handan City, Hebei Province

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VX-770

CAS NO.873054-44-5

  • FOB Price: USD: 15.00-50.00 /Metric Ton Get Latest Price
  • Min.Order: 1 Kilogram
  • Payment Terms: L/C,D/A,D/P,T/T
  • Available Specifications:

    medical grade(1-50)Metric Tonmedical grade(50-500)Metric Ton

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Product Details

Keywords

  • Kalydeco
  • Ivacaftor
  • N-[2,4-Bis(tert-butyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxo-3-quinolinecarboxamide

Quick Details

  • ProName: VX-770 873054-44-5
  • CasNo: 873054-44-5
  • Molecular Formula: C24H28N2O3
  • Appearance: Solid
  • Application: medical intermediate
  • DeliveryTime: 5-7 woking day
  • PackAge: 5mg/vial, 10 vials per box
  • Port: Qingdao port, Tianjin port
  • ProductionCapacity: 3000 Kilogram/Month
  • Purity: >99%
  • Storage: 2-8°C
  • Transportation: EMS,DHL,?TNT,?UPS?,FEDEX,?BY?AIR,?BY?S...
  • LimitNum: 1 Kilogram
  • packing: According to your request
  • grade: Medical Grade

Superiority

Our Advantage 

Rich Experience 
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term. 

Quality service 
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product. 
  
24 hour service 
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage. 

High quality 
Dedicated to serving customers first, we provide reasonable prices, high quality products. 

Details

Molecular Formula C24H28N2O3
Molar Mass 392.49
Density 1.187
Melting Point 212-215°C
Boling Point 550.4±50.0 °C(Predicted)
Flash Point 286.7°C
Solubility DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
Vapor Presure 1E-12mmHg at 25°C
Appearance Solid
Color White to Light Brown
pKa 11.08±0.23(Predicted)
Storage Condition Refrigerator
Refractive Index 1.605
Use Ivacaftor (VX-770) is an enhancer of cystic fibrosis transmembrane conduction regulator (CFTR), which targets G551D-CFTR and F508del-CFTR with EC50 of 100 nM and 25 nM respectively.
In vitro study Ivacaftor(10 μm) significantly increased forskolin-stimulated Cl in Fisher rat thyroid (FRT) cells expressing CFTR mutant G551D
In vivo study Ivacaftor acts on cystic fibrosis subjects aged 6 to 11 carrying the G551D mutation and has completed Phase III study.

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