Hebei Nengqian Chemical Import and Export Co., LTD
Assessed Supplier Enterprise Certification
- Assessed
Supplier - 4th
years
Assessed Supplier Enterprise Certification
Product Certification&
Enterprise Certification
Country: 
China (Mainland)
Business Type:Trading Company
Tel: +86 13910575315
Tel: +86 15632961819
Tel: +86 18233902561
Tel: +86 15717685612
Tel: +86 16630923639
Tel: +86 18732968538
Tel: +86 18833033983
Tel: +86 19831957301
Mobile: +86 19831957301
Tel: +86 13910575315
Fax: 0310-8698866
URL: http://hbnq1.com/
Province/state: Hebei
City: Handan
Street: Congtai District, La Defense North
MaxCard:
Ms.AnnaCAS NO.98-92-0
Pharmaceutical grade(1-50)KilogramPharmaceutical grade(51-99)Kilogram
Our Advantage
Rich Experience
Our products are sold all over Europe,North&South America, Sino-East, Asia and pacific area as well as Africa,we establish long term.
Quality service
Company cooperates with research institutes. We strictly control the process of raw materials up to finished product.
24 hour service
Quick and clear response to customers questions. Warm after sale service, we will help to solve the problems in your usage.
High quality
Dedicated to serving customers first, we provide reasonable prices, high quality products.
1) Standard:BP/USP/EP/Enterprise standard
2) All Purity≥99%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out in 24 hours after payment.Tracking number available
2) Secure and discreet shipment.Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe,
and we have stock in there for transferring.
| Introduction | nicotinamide, also known as nicotinamide, vitamin B3 or vitamin PP, is a water-soluble vitamin, belonging to B vitamins, it is a component of coenzyme I (nicotinamide adenine dinucleotide, NAD) and coenzyme II (nicotinamide adenine dinucleotide phosphate, NADP), in the human body, the nicotinamide part of these two coenzyme structures has reversible hydrogenation and dehydrogenation properties, plays a role in hydrogen transfer in biological oxidation, and can promote tissue respiration, biological oxidation process and metabolism, it is important to maintain the integrity of normal tissues, especially the skin, digestive tract and nervous system. Lack of, due to the cell's respiratory and metabolic effects caused by pellagra, so this product is mainly used for the prevention and treatment of pellagra, stomatitis, glossitis, etc. |
| Food Source | naturally occurs mainly in the grain coat, yeast, peanut, meat, animal organs, milk and green leafy vegetables, the body can be synthesized from tryptophan, but the efficiency is very low. Nicotinic acid can be synthesized by Escherichia coli and the like in the intestinal tract and then converted into nicotinamide. |
| Application | nicotinamide and nicotinic acid are common in most combinations, and nicotinic acid also produces nicotinamide in animals. In the absence of nicotinic acid and nicotinamide, pellagra develops. They can therefore prevent pellagra. They play a role in the metabolism of proteins and sugars, improving the nutrition of humans and animals. In addition to being used as medicine, it is also widely used as food and feed additives. Worldwide production capacity has exceeded 30,000 tons. In Japan, nicotinamide for medicine accounted for 40%, feed additives accounted for 50%. Food additives accounted for 10%. Nicotinic acid and nicotinamide are non-toxic, and the LD50 of nicotinamide injected subcutaneously to rats is 1.7g/kg, which is naturally contained in animal liver, kidney, yeast and rice sugar. |
| usage limit | GB 14880-94: same as "01017, niacin". is subject to GMP (FDA § 184.1535,2000). Japan (1998): wheat flour 35 mg/kg; Rice 7 mg/kg; Modified milk powder 4 mg/kg; Meat color auxiliary 0.02% ~ 0.1% (combined with vitamin C). Maintain and enhance the color, flavor and taste of ham and sausage. Shall not be used for meat and fresh fish shellfish, cetaceans. |
| whitening principle | There are two main whitening principles of nicotinamide: first, nicotinamide can interfere with the transport of melanin, the melanin is restricted in the melanocytes, the melanocytes are prevented from producing melanin, and the melanin is prevented from being transmitted to the skin surface to make the skin black, so as to achieve the whitening effect. Second, nicotinamide has been proved to have a good anti-glycation effect, and the substance produced by the skin saccharification is brown, which will make the skin look black. The anti-glycation of nicotinamide helps skin whitening, thereby lightening skin tone. |
| efficacy effect | 1. Moisturizing, oil control, reducing niacinamide can be very effective in reducing the loss of water through the skin, although the single effect of hyaluronic acid and glycerol is not good, but the effect of the use of the absolute is 1+1>2; nicotinamide can make the sebaceous glands in the "excited" state calm down, and then achieve the effect of oil control, reducing blackheads and acne. 2. Good anti-wrinkle ability the anti-wrinkle ability of nicotinamide lies in the ability to activate ATP, provide the vitality of keratinocytes, increase the synthesis of collagen, and have a good synergistic ability, it can be used together with other anti-wrinkle ingredients. 3. Good auxiliary sunscreen effect the harm brought by ultraviolet rays to the human body is not only tanning, but also leads to the occurrence of immunosuppression and even skin cancer. Many studies at home and abroad have shown that nicotinamide can effectively reduce the occurrence of skin photoimmune suppression under ultraviolet irradiation. 4. Good mildness compared to vitamin C, resorcinol derivatives and other ingredients, the mildness of nicotinamide is good, many people's skin can also be used, but still pay attention to the problem of skin tolerance, such as The Ordinary whitening essence 10% of The concentration of nicotinamide, or has a certain degree of irritation. Therefore, it is best to first pass the skin tolerance test before use, to determine the tolerance and then start to use, at the same time, be careful not to use with acid products, such as salicylic acid, fruit acid, to prevent excessive irritation to the skin. |
| metabolism and absorption | oral gastrointestinal absorption of nicotinamide, intramuscular injection absorption faster, after absorption and distribution to the body tissues, t1/2 is 45 min. Metabolized by the liver, most of them were metabolized to N-methylnicotinamide, and only a small amount of the treatment was excreted from the urine as the original form, and the excretion increased when the dosage exceeded the need. If the daily urine N-methyl nicotinamide is less than 4mg, it indicates a deficiency of nicotinamide. |
| adverse reactions | occasional dizziness, Nausea, upper abdominal discomfort, loss of appetite, etc, in the early pregnancy overdose may be teratogenic, intramuscular injection can cause pain, so less use. |
| content analysis | accurately weigh 300mg of a sample pre-dried on silica gel for 4H, dissolve in 20ml of glacial acetic acid, if necessary, it was heated slightly for solubilization. After adding 0.1 of benzene and 2 drops of crystal violet test solution (TS-74), the mixture was titrated with mol/L perchloric acid. At the same time, the blank test was carried out and the necessary correction was made. Perchloric acid corresponds to 12.21mg of nicotinamide (C6H6N2O) per mL of 0.1mol/L. Or by high pressure liquid chromatography (GT-10-4). |
| toxicity | LD50 2.5-3.5g/kg (rat, oral). GRAS(FDA,§ 182.5535,2000). No special provisions are made by ADI (EEC,1990). |
| Use | an amide derivative of vitamin B3 and PARP inhibitors vitamins, which participate in the metabolic process in the body, for the prevention and treatment of pellagra and other niacin deficiency The water solubility of nicotinamide is better than that of nicotinic acid, but it is easy to form a complex with vitamin C and agglomerate. Dosage 30-80mg/kg. It is used in skin care products to prevent skin roughness, maintain skin cell health, and promote skin whitening. For hair care can promote scalp blood circulation, healthy hair follicles, promote hair growth, prevent baldness. biochemical research; Nutrient composition of tissue culture medium; Clinical drug is vitamin B group, which is used to prevent and treat pellagra, stomatitis, glossitis and other diseases. |
| production method | β-picoline is oxidized to nicotinic acid by air, it was prepared by heating and dehydration. niacin, boric acid and ammonia water are put into the reaction pan, and ammonia gas is introduced into the reaction pan under stirring to increase the temperature to dissolve; Then the ammonia is distilled and recovered to 120 ~ C, and then transferred into the dehydration pan to continue concentration; the addition of liquid ammonia was started after the temperature reached 145 ° C., and the reaction was continued at 185-190 ° C. For 20-30 hours. Then cool down to 130 ℃, dilute with distilled water, add activated carbon, and decolorize with ammonia at 70~80 ~ C for 2H; After reaction, filter while hot, and cool the filtrate in water for 24h, the crystals were isolated, washed with ethanol and dried to obtain a final product with a yield of 89%. niacin, boric acid and ammonia water are put into the reaction pan, and ammonia gas is introduced into the reaction pan under stirring, then the temperature is raised and the ammonia is recovered by distillation. After reaching 120 ℃, the ammonia is transferred into the dehydration Pan and concentrated, The addition of liquid ammonia was started when the temperature reached 145 °c and the ammonia-passing reaction was continued for 20-30H at 185-190 °c. Then cool down to 130 ℃, dilute with distilled water, add activated carbon, and decolorize with ammonia at 70-80 ℃ for 2H. After reaction, filter while hot, cool the filtrate in water for 24h, separate and crystallize, the product was obtained by washing and drying with ethanol, and the yield was 89% . The product was obtained by salifying nicotinic acid with ammonia water and then dehydrating it. |
| spontaneous combustion temperature | 480°C |
Authoritative Data Verified Data
pH
This product l .O g, add water 10ml to dissolve, according to the law (General 0631),p H value is 5. 5~7. 5.
clarity and color of solution
take this product l.O g, add water to dissolve after 10ml, check according to law (General rule 0901 and general rule 0902), the solution should be clear and colorless.
easily carbonized
take 0.20g of this product, check according to law (General rule 0842), and control solution (take 1.0 of cobalt chloride solution for color comparison, ml of potassium dichromate solution for color comparison, colorimetric copper sulfate liquid l_0 m l, diluted with water to 50ml) 5 m l comparison, not deeper.
Related substances
take this product, precision weighing, adding ethanol to dissolve and dilute to make a solution containing about 40mg per lm l, as a test solution; Take the appropriate amount of precision, diluted separately with ethanol to make about 0.2mg and 0. lm g solution, as a control solution (1) and (2 ) ; Another appropriate amount of nicotinic acid control, and ethanol dissolved and diluted to make about 0.2M g of solution, as a reference solution; Then take the appropriate amount of nicotinic acid control and this product, add ethanol to dissolve and dilute to make about 1 l/l containing nicotinic acid 0. A mixed solution of 2m g and 1 m g of nicotinamide was used as a control solution (3). According to the thin layer chromatography (General 0502) test, draw 5M1 of each of the above five solutions, respectively, on the same silica gel GF254 thin layer plate, with chloroform-absolute ethanol-water (48 : 45: 4) for the development of the agent, expand, take out, dry, set the UV light (254mn) under the inspection. The control solution (3> should show two clearly separated spots; The control solution (2) should show one clearly visible spot; The test solution should show impurity spots corresponding to the control solution, its color with the
The main spot of the irradiated solution should not be deeper (0.5%); If other impurity spots are shown, it should not be deeper compared with the main spot of the control solution (1).
loss on drying
take this product, put it in a phosphorus pentoxide dryer, and dry it under reduced pressure for 18 hours. The weight loss shall not exceed 0.5% (General rule 0831).
ignition residue
not over 0841 (general rule).
Heavy metals
take this product l .O g, Add 10ml of water to dissolve, add 6m l of lm o L/l hydrochloric acid solution and an appropriate amount of water to make 2 5 m l, and check according to law (General Principles 0821 first law), heavy metals should not be more than 20 parts per million.
arsenic salt
take l .O g of this product, add 2 M l of water and 5m l of hydrochloric acid to dissolve it, and then check it according to law (General rule 0822 first law), and it shall comply with the regulations (0.0002%).
Product Packaging：
1) 1kg/bag (1kg net weight, 1.1kg gross weight, packed in an aluminum foil bag)
2) 25kg/drum (25kg net weight, 28kg gross weight; Packed in a cardboard-drum with two plastic-bags inside; Drum Size: 510mm high, 360mm diameter)
Storage：
Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.
Delivery：
Usually within3-5 working days after full payment.
transport：
EMS,DHL, TNT, UPS ,FEDEX, BY AIR, BY SEA
DHL Express, FedEx and EMS for quantity less than 50KG, usually called as DDU service;
Sea shipping for quantity over 500KG; And air shipping is available for 50KG above;
For high value products, please select air shipping and DHL express for safe;
Our Service:
1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T,, t/t
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.
6. Package: Professional packing with professional materials.
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
P.S.: we accept packaging customization.
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
About us
Our company specializes in processing and selling chemical raw materials, chemical products, pharmaceutical intermediates, veterinary medicine intermediates, dye intermediates, pigments, cosmetics raw materials and chemical reagents,
We have compalete sales and service team , information feedback vertical integration of a sound marketing network, products are sold throughout the country and exported to South Asia, Europe, America, Africa and other more than 20 countries and regions.
Companies adhering to the "pursuit of quality, innovation and development" business philosophy, to serve as a foundation, for the survival by the quality, seek development by science and technology, adhere to quilty comes first,fair price,good sense of customer service and responsibility. in the future hebei Nengqian import and export trade Co.,Ltd will always hold "integrity, innovation" business philosophy, to achieve honesty management, on the way of specialization, internationalization, Keep moving!
FAQ:
1. Are you a trade company or factory
We are a factory with our own trading company.
2.How do you control the quality
Our factory is equipped with professional technicians to control quality, out inspectors take sample for testing every 2 hours to ensure the quality of our production. We also accept BV, SGS or any other Third-party inspection.
3. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
4. Where is your factory located How can I visit the factory
Our factory located in HEBEI, China.
5. Can i get some samples
Yes, we can supply free sample, but the shipping cost be paid by our customers.
6. How to start orders or make payments
Proforma invoice will be sent first after confirmation of order, enclosed our bank information.Payment by T/T,
7. How to confirm the Product Quality before placing orders
You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
8. How long is lead time
We deliver goods within 3 days for small order, 7-10 days for bulk order.
9. How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a realquality problem caused by us, we will send you free goods for replacement or refund your loss.